Ausschuss für Hygiene

Host species:

• natural host: laboratory and wild rats (JACOBY et al. 1979)
• hamsters and other species can be infected experimentally (KILHAM & MARGOLIS 1975, National Research Council 1991)
• mouse cells cannot be infected by H-1 (TATTERSALL & COTMORE 1986)

Properties of the virus:

• highly temperature resistant (FASSOLITIS et al. 1985)
• highly resistant at different pH values, desiccation and other environmental conditions (GREENE 1963, TATTERSALL & COTMORE 1986)

Strain susceptibility:

• none

Organotropism:

• viral replication only in mitotically active tissues like, e.g. embryo, intestines, tumours (JACOBY et al. 1979)
• pathogenic for the developing liver and cerebellum (JACOBY & BALL-GOODRICH 1995)

Clinical disease:

• no clinical signs after natural infection (National Research Council 1991)
• fetal and neonatal abnormalities (KILHAM & MARGOLIS 1975)
• cerebellar hypoplasia and chronic ataxia in young animals after experimental infection (MARGOLIS & KILHAM 1975)

Pathology:

• no lesions after natural infection
• experimental malformations of the central nervous system, skeleton, and teeth (KILHAM & MARGOLIS 1975)
• hepatocellular necrosis after partial hepatectomy (RUFFOLO et al. 1966)

Morbidity and Mortality:

• no clinical signs after natural infection
• mongoloid-like deformations in hamsters experimentally infected as newborns (TOOLAN & LEDINKO 1968)

Zoonotic potential:

• none

Interference with research:

• Physiology

• delayed healing of bone fractures and altered callus formation (KILHAM & MARGOLIS 1975)
• inhibition of lipid formation in rat kidney cells in vitro (SCHUSTER et al. 1991)
• increased abortion rate (KILHAM & MARGOLIS 1969)

  Pathology

• hepatocellular necrosis after partial hepatectomy (RUFFOLO et al. 1966)

  Infectiology

• viral inclusion bodies in animals bearing larval forms of tapeworms (KILHAM et al. 1970)

  Cell biology

• contaminant of permanent human cell lines (HALLAUER et al. 1971)
• infection of human cells is increased after oncogenic transformation (TOOLAN & LEDINKO 1965, DUPRESSOIR et al. 1989, CHEN et al. 1986, ROMMELAERE & CORNELIS 1991)
• human cells naturally or experimentally transformed with DNA tumour viruses are permissive for H-1 infection (FAISST et al. 1989)
• in various human lymphoma-derived cells a persistent infection can occur (FAISST et al. 1990)

  Teratology

• fetal deaths and congenital malformation after inoculation into pregnant hamsters (FERM & KILHAM 1964)

  Infectiology

• H-1 together with KRV and C. piliforme can influence the prevalence rate of Yersinia-induced arthritis in rats (GRIPENBERG-LERCHE & TOIVANEN 1993, 1994)

  Oncology

• greater susceptibility of human oncogenic transformed cells and tumour-derived cell lines than normal untransformed parental cells (CORNELIS et al. 1988, ROMMELAERE & CORNELIS 1991)
• presence of H-1 virus reduces the number of tumours produced by an oncogenic adenovirus in hamsters (TOOLAN & LEDINKO 1968)
• reduced incidence of spontaneous tumours in hamsters experimentally infected at birth (TOOLAN 1967, TOOLAN et al. 1982)
• reduced incidence of chemically induced tumours in experimentally infected hamsters (TOOLAN et al. 1982)
• inhibition of tumour formation in nude mice from a transplanted human tumour and retardation of tumour growth (DUPRESSOIR et al. 1989)

References:

• Chen, Y. Q., F. de Foresta, J. Hertoghs, B. L. Avalosse, J. J. Cornelis, and J. Rommelaere. 1986. Selective killing of simian virus 40-transformed human fibroblasts by parvovirus H-1. Cancer Res. 46:3574-3579.

  Cornelis, J. J., P. Becquart, N. Duponchel, N. Salome, B. L. Avalosse, M. Namba, and J. Rommelaere. 1988. Transformation of human fibroblasts by ionizing radiation, a chemical carcinogen, or simian virus 40 correlates with an increase in susceptibility to the autonomous parvoviruses H-1 virus and minute virus of mice. J. Virol. 62:1679-1686.

  Dupressoir, T., J. M. Vanacker, J. J. Cornelis, N. Duponchel, and J. Rommelaere. 1989. Inhibition by parvovirus H-1 of the formation of tumors in nude mice and colonies in vitro by transformed human mammary epithelial cells. Cancer Res. 49:3203-3208.

  Faisst, S., J. R. Schlehofer, and H. zur Hausen. 1989. Transformation of human cells by oncogenic viruses supports permissiveness for parvovirus H-1 propagation. J. Virol. 63:2152-2158.

  Faisst, S., S. Bartnitzke, J. R. Schlehofer, and H. zur Hausen. 1990. Persistence of parvovirus H-1 DNA in human B- and T-lymphoma cells. Virus Res. 16:211-224.

  Fassolitis, A. C., et al. 1985. Thermal resistance of three parvoviruses: a possible human isolate, the minute virus of mice, and the latent rat virus. J. Food. Protect. 48:4-6.

  Ferm, V. H., and L. Kilham. 1964. Congenital anomalies induced in hamster embryos with H-1 virus. Science 145:510-511.

  Greene, E. L. 1963. Physical and chemical properties of H-1 virus. pH and heat stability of the hemagglutinating property. Proc. Soc. Exp. Biol. Med. 118:973-975.

  Gripenberg-Lerche, C., and P. Toivanen. 1993. Yersinia associated arthritis in SHR rats: effect of the microbial status of the host. Ann. Rheum. Dis. 52:223-228.

  Gripenberg-Lerche, C., and P. Toivanen. 1994. Variability in the induction of experimental arthritis: Yersinia associated arthritis in Lewis rats. Scand. J. Rheumatol. 23:124-127.

  Hallauer, C., G. Kronauer, and G. Siegl. 1971. Parvoviruses as contaminants of permanent human cell lines. I. Virus isolations from 1960 to 1970. Arch. Ges. Virusforsch. 35:80-90.

  Jacoby, R. O., P. N. Bhatt, and A. M. Jonas. 1979. Viral Diseases, in: H. J. Baker, J. R. Lindsey & S. H. Weisbroth (Eds.): The laboratory rat, Vol. 1, Biology and Diseases, Academic Press, New York, 1979.

  Jacoby, R. O., and L. Ball-Goodrich. 1995. Parvovirus infections of mice and rats. Sem. Virol. 6:329-337.

  Kilham, L., and G. Margolis. 1969 Transplacental infection of rats and hamsters induced by oral and parenteral inoculations of H1 and rat viruses (RV). Teratology 2:111-223.

  Kilham. L., G. Margolis, and E. D. Colby. 1970. Enhanced proliferation of H-1 virus in livers of rats infected with Cysticercus fasciolaris. J. Infect Dis. 121:648-652.

  Kilham. L., and G. Margolis. 1975. Problems of human concern arising from animal models of intrauterine and neonatal infections due to viruses: a review. I. Introduction and virologic studies. Progr. Med. Virol. 20:113-143.

  Margolis, G., and L. Kilham. 1975. Problems of human concern arising from animal models of intrauterine and neonatal infections due to viruses: a review. II. Pathologic studies. Progr. Med. Virol. 20:144-179.

  National Research Council, Committee on Infectious Diseases of Mice and Rats. Infectious diseases of mice and rats National Academy Press, Washington, D.C., 1991.

  Rommelaere; J., and J. J Cornelis. 1991. Antineoplastic activity of parvoviruses. J. Virol. Methods 33:233-251.

  Ruffolo, P. R., G. Margolis, and L. Kilham. 1966. The induction of hepatitis by prior partial hepatectomy in resistant adult rats infected with H-1 virus. Am J. Pathol. 49:795-824.

  Schuster, G. S., G. B. Caugham, and N. L. O’Dell. 1991. Altered lipid metabolism in parvovirus-infected cells Microbios. 66:134-155.

  Tattersall, P., and S. F. Cotmore. 1986. The rodent parvoviruses, in: Bhatt, P. N. et al. (Eds.), Viral and mycoplasmal infections of laboratory rodents. Effects on biomedical research. Academic Press Inc., Orlando, 1986.

  Toolan, H. W. 1967 Lack of oncogenic effect of the H-viruses for hamsters. Nature 214:1036.

  Toolan, H. W., and N. Ledinko. 1965. Growth and cytopathogenicity of H-1 viruses in human and simian cell cultures. Nature 214:812-813.

  Toolan, H. W., and N. Ledinko. 1968. Inhibition by H-1 virus of the incidence of tumors produced by adenovirus 12 in hamsters. Virology 35:475-478.

  Toolan, H. W., S. L. Rhode, and J. F. Gierthy. 1982. Inhibition of 7, 12-Dimethylbenz(a)anthracene-induced tumors in syrian hamsters by prior infection with H-1 parvoviruses. Cancer Res. 42:2552-2555.